Clinicopathologic Significance of Heat Shock Protein 60 as a Survival Predictor in Colorectal Cancer

The role of heat shock protein 60 (HSP60), a mitochondrial chaperone, in tumor progression or its anti-tumor effects remains controversial. This study aimed to confirm the possibility using HSP60 as prognostic marker patients with colorectal cancer (CRC), considering TNM classification for precise prediction. expression increased differentiation and p53 mutations patients. However, compared high expression, low had event-free survival disease-specific hazard ratios (HRs) 1.42 1.69, respectively. Moreover, when rate was analyzed by combining prognosis poor, particularly late/advanced stage. pattern also observed HSP family D member 1, HSPD1, gene that encodes HSP60. Low HSPD1 linked lower overall relapse-free rates, HRs 1.80 1.87, When were considered, CRC advanced malignancy poorer than those expression. Thus, HSPD1/HSP60 can be useful biomarker sophisticated prediction late- advanced-stage CRC, allowing design individualized treatment strategies.